New crona virus sequelae and vaccine side effects, which one worries you more？

Judging from recent reports, the situation of the epidemic is improving. At the same time, there are almost no control and restrictions on the epidemic abroad, and people are gradually loosening up and no longer wearing masks when they go out, as if the epidemic is over. Moreover, because many people have Everyone has been vaccinated, so everyone feels guaranteed, but do you understand the side effects and protective power of the vaccine? The following is the comparison information of several main vaccines:

AZ vaccine/side effects and protection
The AZ vaccine was jointly developed by the University of Oxford and AstraZeneca. It has been authorized for use by other advanced countries such as WHO, the European Union, and my country. The AZ vaccine is a non-replicating vaccine containing the SARS-CoV-2 virus spike protein gene. type adenovirus vector vaccine. Victims need to be vaccinated in 2 doses, and the interval between vaccinations is recommended to be more than 8 weeks.

The storage condition of the vaccine is 2-8°C, and the protective power is 70%, which seems to be lower than that of Pfizer vaccine (95%) and Moderna vaccine (94.5%). Shi Xinru mentioned that the clinical trial sites of different brands of vaccines are different, and the infection status of epidemic areas or non-epidemic areas is also different, which may affect the data. As long as it can pass the clinical test and obtain approval, it is a useful vaccine.

The incidence of complications (serious allergic reactions) of the AZ vaccine is about 15.2 per million. A small number of victims may even develop thrombotic thrombocytopenia purpura, which may cause symptoms such as dyspnea, chest pain, and fever. In severe cases, complications may occur. Arrhythmia and myocardial damage.

Minor side effects after vaccination include redness, swelling and pain at the injection site, headache, muscle pain, fever, fatigue, chills, and nausea. In particular, the older you are, the fewer side effects of the AZ vaccine. Luo Yijun, deputy head of the medical response team of the command center, said that young people have a stronger immune system, and the immune response is more severe after vaccination. Most of the side effects are temporary and will resolve on their own after a period of time.

Modena Vaccine / Side Effects and Protection
The Moderna vaccine is an mRNA vaccine developed by Moderna Pharmaceuticals in the United States. mRNA can produce proteins that trigger immune responses and produce antibodies to resist new coronary pneumonia. The storage conditions of the vaccine are -20°C. The shelf life at ~8°C is 30 days. Victims need to receive 2 doses at least 28 days apart.

The protection of the Moderna vaccine is 94%. The side effects after vaccination include pain at the injection site, headache, muscle pain, joint pain, fatigue, chills and fever. According to statistics, the proportion of side effects of the Moderna vaccine is slightly higher than AZ vaccine, but there have been no cases of thrombosis.

High-end vaccine, Lianya vaccine/side effects and protection
For domestic vaccines, Lianya vaccine and high-end vaccines are recombinant protein vaccines. The virus spine protein is produced by gene recombination, and the vaccine is made into the immune system to generate an immune response. The storage temperature is 2-8°C, and the protective power It is not yet clear that the second-phase trials of the two domestic vaccines have entered the final stage, and the test data can be released around June.

BNT Pfizer Vaccine / Side Effects and Protection
The BNT Pfizer vaccine is an mRNA vaccine jointly developed by the United States and Germany. It has been urgently authorized for use by advanced countries such as the World Health Organization and the European Union. The Pfizer vaccine needs to be stored in ultra-low temperature freezing at -60 to -80°C, and the storage time under refrigeration temperature It was revised in mid-May this year, from the original 5 days to 1 month, and the victim needs to be vaccinated with 2 doses, with an interval of at least 28 days.

The Pfizer vaccine has a protective power of up to 95%. The side effects include redness, swelling and pain at the injection site, headache, muscle pain, joint pain, rash, and fever. The probability of severe allergic reaction is 18.8 per million.

Johnson & Johnson Vaccines / Side Effects and Protection
The Johnson & Johnson vaccine was developed by Johnson & Johnson. It belongs to the same adenovirus vector vaccine as the AZ vaccine. The storage temperature is 2-8°C, and the protective power is 66.3%. The characteristic of the Johnson & Johnson vaccine is that only 1 injection is required The side effects are similar to other vaccines, but the symptoms are milder, but there are very few cases of serious complications such as blood clots and blood clotting disorders.

The new crown epidemic has entered its fourth year, and the number of recovered patients and repeated infections has increased over time. The subtype strains BA.1 and BA.2 of the latest virus variant Omicron have successively dominated the global epidemic and are more contagious, but in vaccines Under the influence of several factors such as the general enhancement of natural immunity, the follow-up of drugs and therapy, the severe and fatality rates have been significantly reduced.

At the same time, more attention has turned to long-term symptoms of Covid-19, or “long Covid-19,” including adults and minors.

The new coronavirus only emerged at the end of 2019, and the global pandemic began in early 2020. Therefore, long-term data studies are lacking, and the existing definitions can only be based on small-scale samples and short follow-up observations.

Whether the long-term symptoms of the new crown will disappear, whether the patient will recover, and how long the sequelae can last, these questions are still unanswered. The Lancet, an authoritative world medical journal, said in an article in August 2021 that long-term symptoms of the new crown are the number one challenge of modern medicine.

What are the long-term symptoms of the new crown?
The WHO said in an official statement that the long-term symptoms of the new crown are the sequelae of the new crown. According to the clinical definition published by the World Health Organization in October 2021, this symptom usually occurs in people who have been diagnosed with or may be infected with the new coronavirus, and usually “appear within 3 months of infection, persist for at least 2 months, and cannot be explained by other diagnoses”.

There is currently no uniform standard for the “long-term” time span. A UK study says it will follow up for 25 years. It has only been more than two years since the initial discovery of the new coronavirus, which requires a longer period of observation and the accumulation of relevant data.

According to British medical staff guidelines, symptoms that last for more than 12 weeks and cannot be explained by other reasons should be classified as “long new crown”. These symptoms may include:

extremely tired
shortness of breath, chest pain, or tightness
Memory and concentration problems (“brain fog”)
Changes in taste and smell
joint pain
Symptoms, severity, and medical history vary from person to person. The most common symptom by far is severe fatigue.

Other symptoms include: muscle pain, hearing and vision problems, headaches, loss of taste and smell, and damage to the heart, lungs, kidneys, and intestines, diarrhea, and mental health problems including depression, anxiety, and distracted thinking.

Therefore, NINGBO CHANGQI （DoctorClean®) reminds everyone not to relax completely because the current epidemic situation has improved. Wear masks, wash your hands frequently, and maintain social distance. You still need to pay attention.